Giacomo Cantelmo (13 June, 1645 – 11 December, 1702) was a Roman Catholic cardinal from 1690 to 1702.
Giacomo Cantelmo was born in Naples on June 13, 1645, the son of Fabrizio Cantelmo, 5th Duke of Popoli and prince of Pettorano, and Beatrice Brancia, duchess of Padula. The family's surname is sometimes given as Cantelmo-Stuart because they were related to James II of England. Restaino Cantelmo-Stuart was his younger brother.
Prior to attending university, Cantelmo had mastered Latin, Greek, and Hebrew. He was educated at the Sapienza University of Rome and at the University of Bologna.
Pope Innocent XI named him abbot in commendam of San Antonio di Vienna in Naples. On June 4, 1678, he was named inquisitor of Malta. He served as Referendary of the Apostolic Signatura.
On September 27, 1683, he was elected Titular Archbishop of Caesarea. He was consecrated as a bishop by Cardinal Carlo Pio di Savoia, Titular Bishop of Sabina, on October 3, 1683. He became nuncio to Vienna in 1683. He then served as nuncio to Switzerland from April 18, 1685 to December 10, 1687. On October 23, 1688, he was named nuncio extraordinary to Poland. He became nuncio extraordinary to Austria on October 25, 1689. He then returned to Rome to become secretary of the Sacred Congregation for Bishops and Regulars.