Glucokinase

GCK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1V4S, 1V4T, 3A0I, 3F9M, 3FGU, 3FR0, 3GOI, 3H1V, 3ID8, 3IDH, 3QIC, 3S41, 3VEV, 3VEY, 3VF6, 4DCH, 4DHY, 4ISE, 4ISF, 4ISG, 4IWV, 4IXC, 4L3Q, 4LC9, 3IMX, 4MLE, 4MLH, 4NO7, 4RCH
Identifiers
Aliases	GCK, FGQTL3, GK, GLK, HHF3, HK4, HKIV, HXKP, LGLK, MODY2, glucokinase
External IDs	OMIM: 138079 MGI: 1270854 HomoloGene: 55440 GeneCards: GCK
Genetically Related Diseases
maturity-onset diabetes of the young
Gene ontology Molecular function • transferase activity • nucleotide binding • mannokinase activity • hexokinase activity • phosphotransferase activity, alcohol group as acceptor • glucose binding • kinase activity • catalytic activity • protein binding • fructokinase activity • ATP binding • glucokinase activity Cellular component • cytoplasm • mitochondrion • nucleus • nucleoplasm • cytosol Biological process • regulation of potassium ion transport • positive regulation of glycogen biosynthetic process • NADP metabolic process • glycolytic process • glucose homeostasis • phosphorylation • regulation of insulin secretion • canonical glycolysis • cellular glucose homeostasis • calcium ion import • carbohydrate phosphorylation • cellular response to leptin stimulus • regulation of glycolytic process • negative regulation of gluconeogenesis • cellular response to insulin stimulus • metabolic process • glucose 6-phosphate metabolic process • regulation of glucose transport • glucose transport • positive regulation of insulin secretion • carbohydrate metabolic process • glucose metabolic process • detection of glucose Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2645	103988
Ensembl	ENSG00000106633	ENSMUSG00000041798
UniProt	P35557	P52792
RefSeq (mRNA)	NM_033508 NM_000162 NM_033507	NM_010292 NM_001287386
RefSeq (protein)	NP_000153 NP_277042 NP_277043	NP_001274315.1 NP_034422.2 NP_001274315 NP_034422
Location (UCSC)	Chr 7: 44.14 – 44.2 Mb	Chr 11: 5.9 – 5.95 Mb
PubMed search

Glucokinase
Structures of Escherichia coli ATP-dependent glucokinase.
Identifiers
Symbol	Glucokinase
Pfam	PF02685
Pfam clan	CL0108
InterPro	IPR003836
SCOP	1q18
SUPERFAMILY	1q18
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

1V4S, 1V4T, 3A0I, 3F9M, 3FGU, 3FR0, 3GOI, 3H1V, 3ID8, 3IDH, 3QIC, 3S41, 3VEV, 3VEY, 3VF6, 4DCH, 4DHY, 4ISE, 4ISF, 4ISG, 4IWV, 4IXC, 4L3Q, 4LC9, 3IMX, 4MLE, 4MLH, 4NO7, 4RCH