Glutathione reductase

GSR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BWC, 1DNC, 1GRA, 1GRB, 1GRE, 1GRF, 1GRG, 1GRH, 1GRT, 1GSN, 1K4Q, 1XAN, 2AAQ, 2GH5, 2GRT, 3DJG, 3DJJ, 3DK4, 3DK8, 3DK9, 3GRS, 3GRT, 4GR1, 4GRT, 5GRT, 1ALG, 3SQP
Identifiers
Aliases	GSR, HEL-75, HEL-S-122m, glutathione reductase
External IDs	OMIM: 138300 MGI: 95804 HomoloGene: 531 GeneCards: GSR
Targeted by Drug
oxiglutatione
Gene ontology Molecular function • flavin adenine dinucleotide binding • glutathione-disulfide reductase activity • NADP binding • electron carrier activity • oxidoreductase activity • oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor Cellular component • cytoplasm • cytosol • mitochondrial matrix • mitochondrion • extracellular exosome • external side of plasma membrane Biological process • nucleobase-containing small molecule interconversion • glutathione metabolic process • response to reactive oxygen species • cell redox homeostasis • oxidation-reduction process • cellular oxidant detoxification Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2936	14782
Ensembl	ENSG00000104687	ENSMUSG00000031584
UniProt	P00390	P47791
RefSeq (mRNA)	NM_001195104 NM_000637 NM_001195102 NM_001195103	NM_010344
RefSeq (protein)	NP_000628 NP_001182031 NP_001182032 NP_001182033	NP_034474.4 NP_034474
Location (UCSC)	Chr 8: 30.68 – 30.73 Mb	Chr 8: 33.65 – 33.7 Mb
PubMed search

glutathione-disulfide reductase
Human GSR with bound glutathione and FADH
Identifiers
EC number	1.8.1.7
CAS number	9001-48-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

1BWC, 1DNC, 1GRA, 1GRB, 1GRE, 1GRF, 1GRG, 1GRH, 1GRT, 1GSN, 1K4Q, 1XAN, 2AAQ, 2GH5, 2GRT, 3DJG, 3DJJ, 3DK4, 3DK8, 3DK9, 3GRS, 3GRT, 4GR1, 4GRT, 5GRT, 1ALG, 3SQP