HACNS1

AGAP1
Identifiers
Aliases	AGAP1, AGAP-1, CENTG2, GGAP1, cnt-g2, ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
External IDs	MGI: 2653690 HomoloGene: 56689 GeneCards: AGAP1
Gene ontology Molecular function • nucleotide binding • GTP binding • phospholipid binding • metal ion binding • GTPase activator activity • GTPase activity Cellular component • cytoplasm Biological process • protein transport • positive regulation of GTPase activity • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	116987	347722
Ensembl	ENSG00000157985	ENSMUSG00000055013
UniProt	Q9UPQ3	Q8BXK8
RefSeq (mRNA)	NM_001037131 NM_001244888 NM_014914	NM_001037136 NM_178119
RefSeq (protein)	NP_001032208 NP_001231817 NP_055729	NP_001032213 NP_835220
Location (UCSC)	Chr 2: 235.49 – 236.13 Mb	Chr 1: 89.45 – 89.9 Mb
PubMed search

116987

347722

ENSG00000157985

ENSMUSG00000055013

Q9UPQ3

Q8BXK8

NM_001037131
NM_001244888
NM_014914

NM_001037136
NM_178119

NP_001032208
NP_001231817
NP_055729

NP_001032213
NP_835220

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 is an enzyme that in humans is encoded by the AGAP1 gene.

CENTG2 belongs to an ADP-ribosylation factor GTPase-activating (ARF-GAP) protein family involved in membrane traffic and actin cytoskeleton dynamics (Nie et al., 2002).[supplied by OMIM]

HACNS1 is located in an intron of the gene CENTG2 (also known as Human Accelerated Region 2). HACNS1 is hypothesized to be a gene enhancer "that may have contributed to the evolution of the uniquely opposable human thumb, and possibly also modifications in the ankle or foot that allow humans to walk on two legs". Evidence to date shows that of the 110,000 gene enhancer sequences identified in the human genome, HACNS1 has undergone the most change during the evolution of humans following the split with the ancestors of chimpanzees.

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Wikipedia