HAMP

HAMP
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1M4E, 1M4F, 2KEF, 3H0T, 4QAE
Identifiers
Aliases	HAMP, HEPC, HFE2B, LEAP1, PLTR, hepcidin antimicrobial peptide
External IDs	OMIM: 606464 HomoloGene: 81623 GeneCards: HAMP
Gene ontology Molecular function • hormone activity • iron channel inhibitor activity • receptor binding Cellular component • cytoplasm • extracellular region • apical cortex • intercalated disc • cell • extracellular space Biological process • negative regulation of ferrous iron export • negative regulation of intestinal absorption • positive regulation of receptor internalization • negative regulation of transcription from RNA polymerase II promoter • killing of cells of other organism • defense response to fungus • negative regulation of iron channel activity • response to iron ion • multicellular organismal iron ion homeostasis • defense response to bacterium • immune response • positive regulation of receptor catabolic process • positive regulation of protein polyubiquitination • negative regulation of ion transmembrane transporter activity • cellular iron ion homeostasis • cellular response to lipopolysaccharide • aging • cellular response to tumor necrosis factor • liver regeneration • cellular response to bile acid • cellular response to interleukin-6 • response to iron ion starvation • response to vitamin A • response to erythropoietin • positive regulation of cell growth involved in cardiac muscle cell development • response to ethanol • acute-phase response • cellular response to X-ray • response to zinc ion • negative regulation of iron ion transmembrane transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	57817	n/a
Ensembl	ENSG00000105697	n/a
UniProt	P81172	n/a
RefSeq (mRNA)	NM_021175	n/a
RefSeq (protein)	NP_066998	n/a
Location (UCSC)	Chr 19: 35.28 – 35.29 Mb	n/a
PubMed search		n/a

1M4E, 1M4F, 2KEF, 3H0T, 4QAE

57817

n/a

ENSG00000105697

n/a

P81172

n/a

NM_021175

n/a

NP_066998

n/a

Hepcidin is a protein that in humans is encoded by the HAMP gene.

The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta sheet structures. These peptides exhibit antimicrobial activity. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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