HIVEP3

HIVEP3
Identifiers
Aliases	HIVEP3, Hivep3, 2900056N03Rik, A130075N07, AI848000, E030045D18Rik, KBP-1, KBP1, Krc, Rc, Schnurri-3, Shn3, Zas3, ZNF40C, human immunodeficiency virus type I enhancer binding protein 3
External IDs	MGI: 106589 HomoloGene: 7803 GeneCards: HIVEP3
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • transcription regulatory region DNA binding • sequence-specific DNA binding • DNA binding • metal ion binding • nucleic acid binding Cellular component • cytoplasm • nucleus Biological process • multicellular organism development • skeletal muscle cell differentiation • positive regulation of transcription, DNA-templated • regulation of transcription, DNA-templated • transcription from RNA polymerase II promoter • signal transduction • transcription, DNA-templated Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	59269	16656
Ensembl	ENSG00000127124	ENSMUSG00000028634
UniProt	Q5T1R4	A2A884
RefSeq (mRNA)	NM_001127714 NM_024503	NM_010657
RefSeq (protein)	NP_001121186 NP_078779	NP_034787.2 NP_034787
Location (UCSC)	Chr 1: 41.51 – 42.04 Mb	Chr 4: 119.73 – 120.14 Mb
PubMed search

59269

16656

ENSG00000127124

ENSMUSG00000028634

Q5T1R4

A2A884

NM_001127714
NM_024503

NM_010657

NP_001121186
NP_078779

NP_034787.2
NP_034787

Transcription factor HIVEP3 is a protein that in humans is encoded by the HIVEP3 gene.

Members of the ZAS family, such as ZAS3 (HIVEP3), are large proteins that contain a ZAS domain, a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine -rich sequence. These proteins bind specific DNA sequences, including the kappa-B motif (GGGACTTTCC), in the promoters and enhancer regions of several genes and viruses, including human immunodeficiency virus (HIV). ZAS genes span more than 150 kb and contain at least 10 exons, one of which is longer than 5.5 kb (Allen and Wu, 2004).[supplied by OMIM]

It regulates osteoblasts.

HIVEP3 has been shown to interact with TRAF1 and TRAF2.

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Wikipedia