HK3

HK3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3HM8
Identifiers
Aliases	HK3, HKIII, HXK3, hexokinase 3
External IDs	MGI: 2670962 HomoloGene: 55633 GeneCards: HK3
Gene ontology Molecular function • transferase activity • nucleotide binding • mannokinase activity • hexokinase activity • phosphotransferase activity, alcohol group as acceptor • glucose binding • kinase activity • catalytic activity • fructokinase activity • ATP binding • glucokinase activity Cellular component • cytosol • mitochondrion • extracellular region • secretory granule lumen • ficolin-1-rich granule lumen Biological process • glycolytic process • phosphorylation • canonical glycolysis • cellular glucose homeostasis • carbohydrate phosphorylation • hexose metabolic process • metabolic process • glucose transport • glucose 6-phosphate metabolic process • carbohydrate metabolic process • neutrophil degranulation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3101	212032
Ensembl	ENSG00000160883	ENSMUSG00000025877
UniProt	P52790	Q3TRM8
RefSeq (mRNA)	NM_002115	NM_001033245 NM_001206390 NM_001206391 NM_001206392
RefSeq (protein)	NP_002106	NP_001028417.1 NP_001193319.1 NP_001028417 NP_001193319 NP_001193320 NP_001193321
Location (UCSC)	Chr 5: 176.88 – 176.9 Mb	Chr 13: 55.01 – 55.02 Mb
PubMed search

3HM8

3101

212032

ENSG00000160883

ENSMUSG00000025877

P52790

Q3TRM8

NM_002115

NM_001033245
NM_001206390
NM_001206391
NM_001206392

NP_002106

NP_001193321

Hexokinase 3 also known as HK3 is an enzyme which in humans is encoded by the HK2 gene on chromosome 5.Hexokinases phosphorylate glucose to produce glucose-6-phosphate (G6P), the first step in most glucose metabolism pathways. This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose-6-phosphate. [provided by RefSeq, Apr 2009]

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