HMG-CoA reductase

HMGCR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1DQ8, 1DQ9, 1DQA, 1HW8, 1HW9, 1HWI, 1HWJ, 1HWK, 1HWL, 2Q1L, 2Q6B, 2Q6C, 2R4F, 3BGL, 3CCT, 3CCW, 3CCZ, 3CD0, 3CD5, 3CD7, 3CDA, 3CDB
Identifiers
Aliases	HMGCR, HMG-CoA reductase, Entrez 3156, LDLCQ3, 3-hydroxy-3-methylglutaryl-CoA reductase, Hydroxymethylglutaryl-CoA reductase
External IDs	OMIM: 142910 MGI: 96159 HomoloGene: 30994 GeneCards: HMGCR
Targeted by Drug
atorvastatin, cerivastatin, Fluvastatin, lovastatin, mevastatin, pravastatin, rosuvastatin, simvastatin
Gene ontology Molecular function • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor • protein homodimerization activity • hydroxymethylglutaryl-CoA reductase (NADPH) activity • protein binding • NADP binding • NADPH binding • coenzyme binding • protein phosphatase 2A binding • oxidoreductase activity • hydroxymethylglutaryl-CoA reductase activity Cellular component • integral component of membrane • endoplasmic reticulum membrane • membrane • intracellular membrane-bounded organelle • peroxisomal membrane • endoplasmic reticulum Biological process • visual learning • steroid metabolic process • sterol biosynthetic process • negative regulation of striated muscle cell apoptotic process • coenzyme A metabolic process • response to nutrient • positive regulation of skeletal muscle tissue development • lipid metabolic process • positive regulation of cardiac muscle cell apoptotic process • negative regulation of insulin secretion involved in cellular response to glucose stimulus • aging • negative regulation of apoptotic process • cholesterol metabolic process • protein tetramerization • isoprenoid biosynthetic process • negative regulation of MAP kinase activity • positive regulation of cell proliferation • positive regulation of ERK1 and ERK2 cascade • negative regulation of wound healing • cholesterol biosynthetic process • ubiquinone metabolic process • myoblast differentiation • response to ethanol • oxidation-reduction process • positive regulation of stress-activated MAPK cascade • positive regulation of smooth muscle cell proliferation • steroid biosynthetic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3156	15357
Ensembl	ENSG00000113161	ENSMUSG00000021670
UniProt	P04035	Q01237
RefSeq (mRNA)	NM_000859 NM_001130996	NM_008255
RefSeq (protein)	NP_000850 NP_001124468 NP_000850.1	NP_032281.2 NP_032281
Location (UCSC)	Chr 5: 75.34 – 75.36 Mb	Chr 13: 96.65 – 96.67 Mb
PubMed search

HMG-CoA reductase
EC number	{{{EC_number}}}
Gene Ontology	AmiGO / EGO

hydroxymethylglutaryl-CoA reductase
Identifiers
EC number	1.1.1.88
CAS number	37250-24-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

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PMC	articles
PubMed	articles
NCBI	proteins

hydroxymethylglutaryl-CoA reductase
Identifiers
EC number	1.1.1.34
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Search
PMC	articles
PubMed	articles
NCBI	proteins

1DQ8, 1DQ9, 1DQA, 1HW8, 1HW9, 1HWI, 1HWJ, 1HWK, 1HWL, 2Q1L, 2Q6B, 2Q6C, 2R4F, 3BGL, 3CCT, 3CCW, 3CCZ, 3CD0, 3CD5, 3CD7, 3CDA, 3CDB

3156

15357

ENSG00000113161

...
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