HMGA2

Identifiers

HMGA2, BABL, HMGI-C, HMGIC, LIPO, STQTL9, high mobility group AT-hook 2

External IDs

Gene ontology
Molecular function	• DNA binding • DNA-dependent protein kinase activity • core promoter binding • transcription factor activity, transcription factor binding • MH1 domain binding • 5'-deoxyribose-5-phosphate lyase activity • AT DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcription factor binding • C2H2 zinc finger domain binding • regulatory region DNA binding • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • MH2 domain binding • protein binding • DNA-(apurinic or apyrimidinic site) lyase activity • nucleosomal DNA binding • DNA binding, bending • SMAD binding • cAMP response element binding
Cellular component	• SMAD protein complex • senescence-associated heterochromatin focus • nuclear chromosome • protein-DNA complex • chromatin • nucleus • nucleoplasm
Biological process	• positive regulation of transcription from RNA polymerase II promoter • positive regulation of cell cycle arrest • positive regulation of transcription regulatory region DNA binding • regulation of cell cycle process • regulation of transcription, DNA-templated • endodermal cell differentiation • chondrocyte differentiation • senescence-associated heterochromatin focus assembly • regulation of cellular response to drug • negative regulation of DNA binding • response to virus • regulation of stem cell population maintenance • negative regulation of apoptotic process • positive regulation of cellular response to X-ray • negative regulation of transcription from RNA polymerase II promoter • chromatin organization • heterochromatin assembly • oncogene-induced cell senescence • stem cell differentiation • GO:0006350 transcription, DNA-templated • histone H2A-S139 phosphorylation • multicellular organism development • positive regulation of transcription, DNA-templated • negative regulation by host of viral transcription • cell division • positive regulation of gene expression • mesenchymal cell differentiation • chromosome condensation • negative regulation of double-strand break repair via nonhomologous end joining • chondrocyte proliferation • positive regulation of cellular senescence • positive regulation of response to DNA damage stimulus • epithelial to mesenchymal transition • positive regulation of apoptotic process • mesodermal cell differentiation • regulation of growth • cell cycle • mitotic G2 DNA damage checkpoint • negative regulation of transcription, DNA-templated • positive regulation of stem cell proliferation • fat cell differentiation • chromosome breakage • mesodermal-endodermal cell signaling • base-excision repair • negative regulation of single stranded viral RNA replication via double stranded DNA intermediate • DNA damage response, detection of DNA damage • transcription from RNA polymerase II promoter
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


8091


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Ensembl


ENSG00000149948


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UniProt


P52926


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RefSeq (mRNA)

NM_003484 NM_001015886 NM_001300918 NM_001300919 NM_003483
NM_001330190


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RefSeq (protein)


NP_001287847 NP_001287848 NP_001317119 NP_003474 NP_003475


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Location (UCSC)

Chr 12: 65.82 – 65.97 Mb

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PubMed search

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NP_001287847
NP_001287848
NP_001317119
NP_003474
NP_003475

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High-mobility group AT-hook 2, also known as HMGA2, is a protein that, in humans, is encoded by the HMGA2 gene.

This gene encodes a protein that belongs to the non-histone chromosomal high-mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhanceosome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with lipomas suggests a role in adipogenesis and mesenchymal differentiation. A gene knock-out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

The expression of HMGA2 in adult tissues is commonly associated with both malignant and benign tumor formation, as well as certain characteristic cancer-promoting mutations. Homologous proteins with highly conserved sequences are found in other mammalian species, including lab mice (Mus musculus).

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