HOXA11

HOXA11
Identifiers
Aliases	HOXA11, HOX1, HOX1I, RUSAT1, homeobox A11
External IDs	MGI: 96172 HomoloGene: 4033 GeneCards: HOXA11
Gene ontology Molecular function • sequence-specific DNA binding • DNA binding Cellular component • transcription factor complex • protein complex • protein-DNA complex • nucleus • nucleoplasm Biological process • cartilage development involved in endochondral bone morphogenesis • skeletal system development • proximal/distal pattern formation • regulation of chondrocyte differentiation • male gonad development • regulation of transcription, DNA-templated • organ induction • anatomical structure morphogenesis • embryonic digit morphogenesis • transcription, DNA-templated • single fertilization • uterus development • multicellular organism development • positive regulation of transcription, DNA-templated • branching involved in ureteric bud morphogenesis • developmental growth • embryonic limb morphogenesis • positive regulation of chondrocyte differentiation • spermatogenesis • positive regulation of cell development • regulation of gene expression • embryonic skeletal joint morphogenesis • metanephros development • mesodermal cell fate specification • dorsal/ventral pattern formation • embryonic forelimb morphogenesis • anterior/posterior pattern specification • bone development Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3207	15396
Ensembl	ENSG00000005073	ENSMUSG00000038210
UniProt	P31270	P31311
RefSeq (mRNA)	NM_005523	NM_010450
RefSeq (protein)	NP_005514	NP_034580
Location (UCSC)	Chr 7: 27.18 – 27.19 Mb	Chr 6: 52.24 – 52.25 Mb
PubMed search

3207

15396

ENSG00000005073

ENSMUSG00000038210

P31270

P31311

NM_005523

NM_010450

NP_005514

NP_034580

Homeobox protein Hox-A11 is a protein that in humans is encoded by the HOXA11 gene.

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this gene can cause radioulnar synostosis with amegakaryocytic thrombocytopenia.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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