HOXA9

HOXA9
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1PUF
Identifiers
Aliases	HOXA9, ABD-B, HOX1, HOX1.7, HOX1G, homeobox A9
External IDs	MGI: 96180 HomoloGene: 7766 GeneCards: HOXA9
Gene ontology Molecular function • sequence-specific DNA binding • DNA binding • protein binding • enzyme binding Cellular component • nucleus Biological process • regulation of transcription, DNA-templated • endothelial cell activation • transcription, DNA-templated • multicellular organism development • negative regulation of myeloid cell differentiation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3205	15405
Ensembl	ENSG00000078399	ENSMUSG00000038227
UniProt	P31269	P09631
RefSeq (mRNA)	NM_152739	NM_001277238 NM_010456
RefSeq (protein)	NP_689952	NP_034586.1 NP_001264167 NP_034586
Location (UCSC)	Chr 7: 27.16 – 27.18 Mb	Chr 6: 52.22 – 52.23 Mb
PubMed search

1PUF

3205

15405

ENSG00000078399

ENSMUSG00000038227

P31269

P09631

NM_152739

NM_001277238
NM_010456

NP_689952

NP_034586.1
NP_001264167
NP_034586

Homeobox protein Hox-A9 is a protein that in humans is encoded by the HOXA9 gene.

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is highly similar to the abdominal-B (Abd-B) gene of Drosophila fly. A specific translocation event which causes a fusion between this gene and the NUP98 gene has been associated with myeloid leukemogenesis.

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