HOXD10

HOXD10
Identifiers
Aliases	HOXD10, HOX4, HOX4D, HOX4E, Hox-4.4, homeobox D10
External IDs	MGI: 96202 HomoloGene: 1619 GeneCards: HOXD10
Gene ontology Molecular function • sequence-specific DNA binding • DNA binding • transcription factor activity, sequence-specific DNA binding • chromatin binding Cellular component • nucleus • P-body • nucleoplasm • cytosol Biological process • embryonic skeletal system morphogenesis • forelimb morphogenesis • peripheral nervous system neuron development • skeletal system development • proximal/distal pattern formation • regulation of transcription, DNA-templated • spinal cord motor neuron cell fate specification • adult locomotory behavior • hindlimb morphogenesis • transcription, DNA-templated • single fertilization • multicellular organism development • neuromuscular process • embryonic limb morphogenesis • regulation of gene expression • skeletal muscle tissue development • anterior/posterior pattern specification • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3236	15430
Ensembl	ENSG00000128710	ENSMUSG00000050368
UniProt	P28358	P28359
RefSeq (mRNA)	NM_002148	NM_013554
RefSeq (protein)	NP_002139	NP_038582.2 NP_038582
Location (UCSC)	Chr 2: 176.11 – 176.12 Mb	Chr 2: 74.69 – 74.7 Mb
PubMed search

3236

15430

ENSG00000128710

ENSMUSG00000050368

P28358

P28359

NM_002148

NM_013554

NP_002139

NP_038582.2
NP_038582

Homeobox D10, also known as HOXD10, is a protein which in humans is encoded by the HOXD10 gene.

This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development.

Mutations in this gene have been associated with Wilms' tumor and congenital vertical talus (also known as "rocker-bottom foot" deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease.

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