HPRT

HPRT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BZY, 1D6N, 1HMP, 1Z7G, 3GEP, 3GGC, 3GGJ, 2VFA, 4IJQ, 4KN6, 4RAB, 4RAC, 4RAD, 4RAN, 4RAO, 4RAQ, 5BSK, 5BRN
Identifiers
Aliases	HPRT1, HGPRT, HPRT, hypoxanthine phosphoribosyltransferase 1
External IDs	OMIM: 308000 MGI: 96217 HomoloGene: 56590 GeneCards: HPRT1
Gene ontology Molecular function • transferase activity • nucleotide binding • protein homodimerization activity • transferase activity, transferring glycosyl groups • hypoxanthine phosphoribosyltransferase activity • guanine phosphoribosyltransferase activity • metal ion binding • protein binding • magnesium ion binding • identical protein binding Cellular component • cytoplasm • extracellular exosome • cytosol Biological process • purine nucleotide biosynthetic process • grooming behavior • cytolysis • purine ribonucleoside salvage • GMP catabolic process • locomotory behavior • dendrite morphogenesis • hypoxanthine metabolic process • guanine salvage • response to amphetamine • purine-containing compound salvage • nucleoside metabolic process • dopamine metabolic process • central nervous system neuron development • lymphocyte proliferation • cerebral cortex neuron differentiation • IMP metabolic process • protein homotetramerization • striatum development • hypoxanthine salvage • adenine metabolic process • positive regulation of dopamine metabolic process • adenine salvage • IMP salvage Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3251	15452
Ensembl	ENSG00000165704	ENSMUSG00000025630
UniProt	P00492	P00493
RefSeq (mRNA)	NM_000194	NM_013556
RefSeq (protein)	NP_000185	NP_038584
Location (UCSC)	Chr X: 134.46 – 134.52 Mb	Chr X: 52.99 – 53.02 Mb
PubMed search

hypoxanthine phosphoribosyltransferase
Identifiers
EC number	2.4.2.8
CAS number	9016-12-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

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PMC	articles
PubMed	articles
NCBI	proteins

1BZY, 1D6N, 1HMP, 1Z7G, 3GEP, 3GGC, 3GGJ, 2VFA, 4IJQ, 4KN6, 4RAB, 4RAC, 4RAD, 4RAN, 4RAO, 4RAQ, 5BSK, 5BRN

3251

15452

ENSG00000165704

ENSMUSG00000025630

P00492

P00493

...
Wikipedia