HU-308

HU-308

Legal status
Legal status	CA: Schedule II
Identifiers
IUPAC name [(1R,2R,5R)-2-[2,6-Dimethoxy-4-(2-methyloctan-2-yl)phenyl]-7,7-dimethyl-4-bicyclo[3.1.1]hept-3-enyl]methanol
CAS Number	1220887-84-2 N
PubChem CID	5311172
UNII	8I5L034D55
Chemical and physical data
Formula	C27H43O3
Molar mass	415.63 g/mol
3D model (Jmol)	Interactive image
SMILES CCCCCCC(C)(C)C1=CC(=C(C(=C1)OC)C2C=C(C3CC2C3(C)C)CO)OC
NY (what is this?)

HU-308 is a drug that acts as a cannabinoid agonist. It is highly selective for the CB₂ receptor subtype, with a selectivity of over 5000x for CB₂ vs CB₁. The synthesis and characterization took place in the laboratory of Prof. Mechoulam at the Hebrew University of Jerusalem in the late 1990s. It has analgesic effects, promotes proliferation of neural stem cells, and protects both liver and blood vessel tissues against oxidative stress via inhibition of TNF-α.

HU-308 is not scheduled at the federal level in the United States.

"HU-308 ([(1R,2R,5R)-2-[2,6-dimethoxy-4-(2-methyloctan-2-yl)phenyl]-7,7-dimethyl-4-bicyclo[3.1.1]hept-3-enyl]methanol)" is a Schedule I controlled substance in the state of Florida making it illegal to buy, sell, or possess in Florida.