Heparin-binding EGF-like growth factor

HBEGF
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1XDT, 2M8S
Identifiers
Aliases	HBEGF, DTR, DTS, DTSF, HEGFL, heparin binding EGF like growth factor
External IDs	OMIM: 126150 MGI: 96070 HomoloGene: 1466 GeneCards: HBEGF
Gene ontology Molecular function • growth factor activity • heparin binding • protein tyrosine kinase activity • Ras guanyl-nucleotide exchange factor activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • epidermal growth factor receptor binding Cellular component • extracellular region • endocytic vesicle membrane • integral component of membrane • membrane • cell surface • plasma membrane • clathrin-coated endocytic vesicle membrane • integral component of plasma membrane • extracellular space Biological process • positive regulation of keratinocyte migration • cell chemotaxis • MAPK cascade • phosphatidylinositol-mediated signaling • signal transduction • wound healing, spreading of epidermal cells • positive regulation of cell migration • positive regulation of protein kinase B signaling • positive regulation of cell growth • muscle organ development • positive regulation of smooth muscle cell proliferation • regulation of heart contraction • negative regulation of elastin biosynthetic process • cell migration • positive regulation of wound healing • positive regulation of GTPase activity • epidermal growth factor receptor signaling pathway • ERBB2 signaling pathway • phosphatidylinositol phosphorylation • peptidyl-tyrosine phosphorylation • regulation of phosphatidylinositol 3-kinase signaling • regulation of cell motility • positive regulation of cell proliferation • positive regulation of peptidyl-tyrosine phosphorylation • negative regulation of ERBB signaling pathway • interleukin-7-mediated signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1839	15200
Ensembl	ENSG00000113070	ENSMUSG00000024486
UniProt	Q99075	Q06186
RefSeq (mRNA)	NM_001945	NM_010415
RefSeq (protein)	NP_001936	NP_034545
Location (UCSC)	Chr 5: 140.33 – 140.35 Mb	Chr 18: 36.5 – 36.52 Mb
PubMed search

1XDT, 2M8S

1839

15200

ENSG00000113070

ENSMUSG00000024486

Q99075

Q06186

NM_001945

NM_010415

NP_001936

NP_034545

Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family of proteins that in humans is encoded by the HBEGF gene.

HB-EGF-like growth factor is synthesized as a membrane-anchored mitogenic and chemotactic glycoprotein. An epidermal growth factor produced by monocytes and macrophages, due to an affinity for heparin is termed HB-EGF. It has been shown to play a role in wound healing, cardiac hypertrophy, and heart development and function. First identified in the conditioned media of human macrophage-like cells, HB-EGF is an 87-amino acid glycoprotein that displays highly regulated gene expression. Ectodomain shedding results in the soluble mature form of HB-EGF, which influences the mitogenicity and chemotactic factors for smooth muscle cells and fibroblasts. The transmembrane form of HB-EGF is the unique receptor for diphtheria toxin and functions in juxtacrine signaling in cells. Both forms of HB-EGF participate in normal physiological processes and in pathological processes including tumor progression and metastasis, organ hyperplasia, and atherosclerotic disease. HB-EGF can bind two locations on cell surfaces: heparan sulfate proteoglycans and EGF-receptor effecting cell to cell interactions.

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