Hereditary breast-ovarian cancer syndrome

Hereditary breast–ovarian cancer syndrome
Ovarian and breast cancer patients in a pedigree chart of a family
Classification and external resources
ICD-10	C50  C56
OMIM	604370
Orphanet	145
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Hereditary breast–ovarian cancer syndromes (HBOC) are cancer syndromes that produce higher than normal levels of breast cancer and ovarian cancer in genetically related families (either one individual had both, or several individuals in the pedigree had one or the other disease). The hereditary factors may be proven or suspected to cause the pattern of breast and ovarian cancer occurrences in the family.

Approximate proportion of hereditary breast cancer cases caused by each gene

A number of genes are associated with HBOC. The most common of the known causes of HBOC are:

Other identified genes include:

Approximately 45% of HBOC cases involve unidentified genes, or multiple genes.

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