Hermesprota Creek is a 2.2-mile-long (3.5 km) tributary of Darby Creek in Collingdale, Sharon Hill, Darby Township, and Folcroft in Delaware County, Pennsylvania. Its watershed has an area of 1.83 square miles (4.7 km2).
Hermesprota Creek begins in the Har Zion Cemetery near the community of Collingdale, Pennsylvania. It flows south-southeast for several tenths of a mile before passing under U.S. Route 13 and turns west and enters Sharon Hill, Pennsylvania. The creek turns south and enters the communities of Darby Township and Folcroft. Hermesprota Creek then enters the John Heinz National Wildlife Refuge and receives two small unnamed tributaries, from the right and left banks respectively. After several hundred feet, it reaches its confluence with Darby Creek.
Hermesprota Creek joins Darby Creek 3.55 miles (5.71 km) upriver of its mouth.
The water quality of Hermesprota Creek is poor. High amounts of lead, selenium, and zinc were found in sediment in the creek. Hazardous materials were dumped into the creek from 1953 to the 1970s, when the adjacent Folcroft Landfill was closed. The southern part of the creek is tidally influenced.
The elevation near the mouth of Hermesprota Creek is 0 feet (0 m) above sea level. The elevation of the creek's source is between 60 and 80 feet (18 and 24 m) above sea level.
The watershed of Hermesprota Creek has an area of 1.83 square miles (4.7 km2). The entire creek is in the United States Geological Survey quadrangle of Lansdowne.