Histidine ammonia-lyase

HAL
Identifiers
Aliases	HAL, HIS, HSTD, histidine ammonia-lyase, Histidine ammonia-lyase
External IDs	OMIM: 609457 MGI: 96010 HomoloGene: 68229 GeneCards: HAL
Gene location (Human) Chr. Chromosome 12 (human) Band 12q23.1 Start 95,972,662 bp End 95,996,365 bp
Gene ontology Molecular function • catalytic activity • lyase activity • ammonia-lyase activity • histidine ammonia-lyase activity Cellular component • cytosol • cytoplasm Biological process • histidine metabolic process • histidine catabolic process to glutamate and formate • histidine catabolic process to glutamate and formamide • histidine catabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3034	15109
Ensembl	ENSG00000084110	ENSMUSG00000020017
UniProt	P42357	P35492
RefSeq (mRNA)	NM_001258333 NM_001258334 NM_002108	NM_010401
RefSeq (protein)	NP_001245262 NP_001245263 NP_002099	NP_034531
Location (UCSC)	Chr 12: 95.97 – 96 Mb	n/a
PubMed search

histidine ammonia-lyase
Identifiers
EC number	4.3.1.3
CAS number	9013-75-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Search
PMC	articles
PubMed	articles
NCBI	proteins

3034

15109

ENSG00000084110

ENSMUSG00000020017

P42357

P35492

NM_001258333
NM_001258334
NM_002108

NM_010401

NP_001245262
NP_001245263
NP_002099

NP_034531

Histidine ammonia-lyase (or histidase, or histidinase) is an enzyme that in humans is encoded by the HAL gene. Histidase converts histidine into ammonia and urocanic acid.

Histidine ammonia-lyase is a cytosolic enzyme catalyzing the first reaction in histidine catabolism, the nonoxidative deamination of L-histidine to trans-urocanic acid. The reaction is catalyzed by an electrophilic co-factor which is formed autocatalytically by cyclization of the protein backbone of the enzyme.

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Wikipedia