Histidine ammonialyase
| HAL | |||||||||||||||||
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| Aliases | HAL, HIS, HSTD, histidine ammonia-lyase, Histidine ammonia-lyase | ||||||||||||||||
| External IDs | OMIM: 609457 MGI: 96010 HomoloGene: 68229 GeneCards: HAL | ||||||||||||||||
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| Species | Human | Mouse | |||||||||||||||
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| Location (UCSC) | Chr 12: 95.97 – 96 Mb | Chr 10: 93.49 – 93.52 Mb | |||||||||||||||
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| histidine ammonia-lyase | |||||||||
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| EC number | 4.3.1.3 | ||||||||
| CAS number | 9013-75-6 | ||||||||
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| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
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| PMC | articles |
| PubMed | articles |
| NCBI | proteins |
NM_001258333
NM_001258334
NM_002108
NP_001245262
NP_001245263
NP_002099
Histidine ammonia-lyase (or histidase, or histidinase) is an enzyme that in humans is encoded by the HAL gene. Histidase converts histidine into ammonia and urocanic acid.
Histidine ammonia-lyase is a cytosolic enzyme catalyzing the first reaction in histidine catabolism, the nonoxidative deamination of L-histidine to trans-urocanic acid. The reaction is catalyzed by an electrophilic co-factor which is formed autocatalytically by cyclization of the protein backbone of the enzyme.
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Wikipedia