House on Old Lonesome Road is a full-length album by country singer Conway Twitty. It was released in 1989 on MCA Records, and features the hit "She's Got a Single Thing in Mind", which Allmusic's Jason Ankeny called "the energizing hit which reaffirmed Twitty's standing among the era's country's giants."

"Play, Ruby, Play" was later released as a single by Clinton Gregory.

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