IGF1R

IGF1R
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1IGR, 1JQH, 1K3A, 1M7N, 1P4O, 2OJ9, 2ZM3, 3D94, 3F5P, 3I81, 3LVP, 3LW0, 3NW5, 3NW6, 3NW7, 3O23, 3QQU, 4D2R, 4XSS, 5HZN
Identifiers
Aliases	IGF1R, CD221, IGFIR, IGFR, JTK13, insulin like growth factor 1 receptor, Insulin-like growth factor 1，IGF-1R
External IDs	OMIM: 147370 MGI: 96433 HomoloGene: 30997 GeneCards: IGF1R
Gene location (Human) Chr. Chromosome 15 (human) Band 15q26.3 Start 98,648,971 bp End 98,964,530 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 C|7 37.27 cM Start 67,952,827 bp End 68,233,668 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • insulin-like growth factor binding • insulin receptor binding • insulin binding • kinase activity • phosphatidylinositol 3-kinase binding • insulin-like growth factor-activated receptor activity • protein binding • identical protein binding • transmembrane receptor protein tyrosine kinase activity • insulin receptor substrate binding • protein tyrosine kinase activity • ATP binding • insulin-like growth factor I binding Cellular component • integral component of membrane • membrane • intracellular membrane-bounded organelle • receptor complex • plasma membrane • integral component of plasma membrane • alphav-beta3 integrin-IGF-1-IGF1R complex Biological process • insulin receptor signaling pathway • insulin-like growth factor receptor signaling pathway • phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • positive regulation of cell migration • negative regulation of apoptotic process • protein tetramerization • positive regulation of DNA replication • protein phosphorylation • regulation of JNK cascade • immune response • positive regulation of cell proliferation • inactivation of MAPKK activity • peptidyl-tyrosine autophosphorylation • protein autophosphorylation • phosphatidylinositol 3-kinase signaling • phosphatidylinositol-mediated signaling • signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3480	16001
Ensembl	ENSG00000140443	ENSMUSG00000005533
UniProt	P08069	Q60751
RefSeq (mRNA)	NM_000875 NM_001291858 NM_152452	NM_010513
RefSeq (protein)	NP_000866 NP_001278787	NP_034643
Location (UCSC)	Chr 15: 98.65 – 98.96 Mb	Chr 15: 67.95 – 68.23 Mb
PubMed search

1IGR, 1JQH, 1K3A, 1M7N, 1P4O, 2OJ9, 2ZM3, 3D94, 3F5P, 3I81, 3LVP, 3LW0, 3NW5, 3NW6, 3NW7, 3O23, 3QQU, 4D2R, 4XSS, 5HZN

3480

16001

ENSG00000140443

ENSMUSG00000005533

...
Wikipedia