IL23R

IL23R
Identifiers
Aliases	IL23R
External IDs	MGI: 2181693 HomoloGene: 16930 GeneCards: IL23R
Genetically Related Diseases
Crohn's disease, ankylosing spondylitis, ulcerative colitis, psoriasis, inflammatory bowel disease
Gene ontology Molecular function • interleukin-23 receptor activity • interleukin-12 receptor binding • protein binding • interleukin-23 binding Cellular component • integral component of membrane • interleukin-23 receptor complex • membrane • receptor complex • plasma membrane Biological process • negative regulation of interleukin-10 production • response to interferon-gamma • positive regulation of interleukin-12 production • immune system process • positive regulation of T cell mediated cytotoxicity • positive regulation of interferon-gamma production • positive regulation of tyrosine phosphorylation of Stat5 protein • regulation of tyrosine phosphorylation of Stat1 protein • positive regulation of osteoclast differentiation • positive regulation of tyrosine phosphorylation of Stat3 protein • positive regulation of T-helper 17 cell lineage commitment • positive regulation of NK T cell activation • positive regulation of natural killer cell proliferation • response to lipopolysaccharide • positive regulation of T-helper 17 type immune response • positive regulation of T-helper 1 type immune response • positive regulation of granulocyte macrophage colony-stimulating factor production • defense response to Gram-negative bacterium • positive regulation of T cell proliferation • positive regulation of memory T cell differentiation • positive regulation of tyrosine phosphorylation of Stat4 protein • positive regulation of interleukin-17 production • innate immune response • inflammatory response • positive regulation of activation of JAK2 kinase activity • positive regulation of activated T cell proliferation • positive regulation of defense response to virus by host • interleukin-23-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	149233	209590
Ensembl	ENSG00000162594	ENSMUSG00000049093
UniProt	Q5VWK5	Q8K4B4
RefSeq (mRNA)	NM_144701	NM_144548
RefSeq (protein)	NP_653302	NP_653131.2 NP_653131
Location (UCSC)	Chr 1: 67.14 – 67.26 Mb	Chr 6: 67.42 – 67.49 Mb
PubMed search

149233

209590

ENSG00000162594

ENSMUSG00000049093

Q5VWK5

Q8K4B4

NM_144701

NM_144548

NP_653302

NP_653131.2
NP_653131

Interleukin 23 receptor is a type I cytokine receptor. IL23R is its human gene.

The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner.

Three variants in the IL23R gene have been shown to protect against Crohn's disease and ulcerative colitis.

Model organisms have been used in the study of IL23R function. A conditional knockout mouse line called Il23r^{tm2a(EUCOMM)Wtsi} was generated at the Wellcome Trust Sanger Institute. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping

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