IL27RA

IL27RA
Identifiers
Aliases	IL27RA, CRL1, IL-27RA, IL27R, TCCR, WSX1, zcytor1, Interleukin 27 receptor, alpha subunit, interleukin 27 receptor subunit alpha
External IDs	MGI: 1355318 HomoloGene: 3562 GeneCards: IL27RA
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.12 Start 14,031,748 bp End 14,053,216 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 C2 Start 84,030,294 bp End 84,042,589 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • transmembrane signaling receptor activity • interleukin-27 receptor activity Cellular component • integral component of membrane • plasma membrane • integral component of plasma membrane • membrane Biological process • negative regulation of type 2 immune response • cell surface receptor signaling pathway • positive regulation of interferon-gamma production • regulation of isotype switching to IgG isotypes • interleukin-27-mediated signaling pathway • positive regulation of T-helper 1 type immune response • immune response • defense response to Gram-positive bacterium • interleukin-12-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9466	50931
Ensembl	ENSG00000104998	ENSMUSG00000005465
UniProt	Q6UWB1	O70394
RefSeq (mRNA)	NM_004843	NM_016671
RefSeq (protein)	NP_004834	NP_057880
Location (UCSC)	Chr 19: 14.03 – 14.05 Mb	Chr 19: 84.03 – 84.04 Mb
PubMed search

9466

50931

ENSG00000104998

ENSMUSG00000005465

Q6UWB1

O70394

NM_004843

NM_016671

NP_004834

NP_057880

Interleukin 27 receptor, alpha is a subunit of the interleukin-27 receptor. IL27RA is its human gene.

In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein.

Interleukin 27 receptor, alpha subunit has been shown to interact with STAT1.

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Wikipedia