IL6R

IL6R
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1N26, 1P9M, 2ARW
Identifiers
Aliases	IL6R, CD126, IL-6R-1, IL-6RA, IL6Q, IL6RA, IL6RQ, gp80, Interleukin-6 receptor, interleukin 6 receptor
External IDs	MGI: 105304 HomoloGene: 474 GeneCards: IL6R
Gene ontology Molecular function • ciliary neurotrophic factor receptor activity • protein homodimerization activity • interleukin-6 receptor binding • interleukin-6 receptor activity • protein binding • cytokine receptor activity • enzyme binding • interleukin-6 binding • ciliary neurotrophic factor binding Cellular component • integral component of membrane • membrane • plasma membrane • extracellular region • cell surface • basolateral plasma membrane • apical plasma membrane • interleukin-6 receptor complex • ciliary neurotrophic factor receptor complex • extracellular space Biological process • positive regulation of activation of Janus kinase activity • response to cytokine • hepatic immune response • extrinsic apoptotic signaling pathway • monocyte chemotaxis • cytokine-mediated signaling pathway • ciliary neurotrophic factor-mediated signaling pathway • positive regulation of leukocyte chemotaxis • negative regulation of interleukin-8 production • interleukin-6-mediated signaling pathway • positive regulation of osteoblast differentiation • defense response to Gram-negative bacterium • acute-phase response • positive regulation of NF-kappaB transcription factor activity • positive regulation of cell proliferation • positive regulation of interleukin-6 production • positive regulation of peptidyl-tyrosine phosphorylation • positive regulation of chemokine production • neutrophil mediated immunity • negative regulation of collagen biosynthetic process • endocrine pancreas development • positive regulation of MAPK cascade • positive regulation of smooth muscle cell proliferation • defense response to Gram-positive bacterium • positive regulation of tyrosine phosphorylation of STAT protein Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3570	16194
Ensembl	ENSG00000160712	ENSMUSG00000027947
UniProt	P08887	P22272
RefSeq (mRNA)	NM_000565 NM_001206866 NM_181359	NM_010559 NM_001310676
RefSeq (protein)	NP_000556 NP_001193795 NP_852004	NP_001297605 NP_034689
Location (UCSC)	Chr 1: 154.41 – 154.47 Mb	Chr 3: 89.86 – 89.91 Mb
PubMed search

1N26, 1P9M, 2ARW

3570

16194

ENSG00000160712

ENSMUSG00000027947

P08887

P22272

NM_000565
NM_001206866
NM_181359

NM_010559
NM_001310676

NP_000556
NP_001193795
NP_852004

NP_001297605
NP_034689

Interleukin 6 receptor (IL6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor.

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