IRAK1

IRAK1
Identifiers
Aliases	IRAK1, IRAK, pelle, interleukin 1 receptor associated kinase 1
External IDs	MGI: 107420 HomoloGene: 37496 GeneCards: IRAK1
Gene ontology Molecular function • transferase activity • protein kinase activity • nucleotide binding • heat shock protein binding • protein homodimerization activity • kinase activity • NF-kappaB-inducing kinase activity • protein binding • protein heterodimerization activity • ATP binding • protein serine/threonine kinase activity Cellular component • membrane • lipid particle • plasma membrane • endosome membrane • interleukin-1 receptor complex • nucleus • cytoplasm • cytosol Biological process • cellular response to heat • response to interleukin-1 • positive regulation of MAP kinase activity • regulation of cytokine-mediated signaling pathway • phosphorylation • cytokine-mediated signaling pathway • immune system process • aging • negative regulation of apoptotic process • activation of NF-kappaB-inducing kinase activity • MyD88-dependent toll-like receptor signaling pathway • toll-like receptor signaling pathway • positive regulation of transcription, DNA-templated • interleukin-1-mediated signaling pathway • protein phosphorylation • JNK cascade • response to lipopolysaccharide • transmembrane receptor protein serine/threonine kinase signaling pathway • activation of MAPK activity • positive regulation of NF-kappaB transcription factor activity • protein oligomerization • positive regulation of I-kappaB kinase/NF-kappaB signaling • protein autophosphorylation • toll-like receptor 9 signaling pathway • cellular response to lipopolysaccharide • negative regulation of NF-kappaB transcription factor activity • nucleotide-binding oligomerization domain containing signaling pathway • positive regulation of type I interferon production • cellular response to hypoxia • lipopolysaccharide-mediated signaling pathway • signal transduction • positive regulation of smooth muscle cell proliferation • toll-like receptor 4 signaling pathway • toll-like receptor 2 signaling pathway • innate immune response Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3654	16179
Ensembl	ENSG00000184216	ENSMUSG00000031392
UniProt	P51617	Q62406
RefSeq (mRNA)	NM_001025242 NM_001025243 NM_001569	NM_001177973 NM_001177974 NM_001177975 NM_001177976 NM_008363
RefSeq (protein)	NP_001020413 NP_001020414 NP_001560	NP_001171445.1 NP_001171447.1 NP_032389.2 NP_001171444 NP_001171445 NP_001171446 NP_001171447 NP_032389
Location (UCSC)	Chr X: 154.01 – 154.02 Mb	Chr X: 74.01 – 74.02 Mb
PubMed search

3654

16179

ENSG00000184216

ENSMUSG00000031392

P51617

Q62406

NM_001025242
NM_001025243
NM_001569

NM_001177973
NM_001177974
NM_001177975
NM_001177976
NM_008363

NP_001020413
NP_001020414
NP_001560

NP_001171446
NP_001171447
NP_032389

Interleukin-1 receptor-associated kinase 1 is an enzyme that in humans is encoded by the IRAK1 gene.

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Wikipedia