ITPR3

ITPR3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3JRR
Identifiers
Aliases	ITPR3, IP3R, IP3R3, inositol 1,4,5-trisphosphate receptor type 3
External IDs	MGI: 96624 HomoloGene: 1675 GeneCards: ITPR3
Gene ontology Molecular function • calcium channel activity • inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity • ion channel activity • protein binding • inositol 1,3,4,5 tetrakisphosphate binding • calcium-release channel activity • inositol hexakisphosphate binding • inositol 1,4,5 trisphosphate binding • calcium ion binding • phosphatidylinositol binding Cellular component • cytoplasm • integral component of membrane • endoplasmic reticulum membrane • membrane • receptor complex • plasma membrane • apical part of cell • integral component of plasma membrane • nucleoplasm • nucleolus • platelet dense tubular network membrane • endoplasmic reticulum • brush border • nucleus • nuclear outer membrane • myelin sheath • neuronal cell body Biological process • sensory perception of umami taste • calcium ion transport into cytosol • regulation of cardiac conduction • regulation of insulin secretion • memory • ion transport • platelet activation • response to calcium ion • sensory perception of bitter taste • calcium ion transmembrane transport • transmembrane transport • transport • sensory perception of sweet taste • inositol phosphate-mediated signaling • calcium ion transport • long-term synaptic potentiation • G-protein coupled receptor signaling pathway • positive regulation of cytosolic calcium ion concentration • protein homooligomerization • protein heterooligomerization • release of sequestered calcium ion into cytosol Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3710	16440
Ensembl	ENSG00000096433	ENSMUSG00000042644
UniProt	Q14573	P70227
RefSeq (mRNA)	NM_002224	NM_080553
RefSeq (protein)	NP_002215	NP_542120.2 NP_542120
Location (UCSC)	Chr 6: 33.62 – 33.7 Mb	Chr 17: 27.06 – 27.12 Mb
PubMed search

3JRR

3710

16440

ENSG00000096433

ENSMUSG00000042644

Q14573

P70227

NM_002224

NM_080553

NP_002215

NP_542120.2
NP_542120

Inositol 1,4,5-trisphosphate receptor, type 3, also known as ITPR3, is a protein which in humans is encoded by the ITPR3 gene. The protein encoded by this gene is both a receptor for inositol triphosphate and a calcium channel.

ITP3 channels serve an important role in the taste transduction pathway of sweet, bitter and umami tastes the gustatory system. ITP3 channels allow the flow of Calcium out of the endoplasmic reticulum in response to IP3. Calcium cations result in the activation of TRPM5 which leads to a depolarisation generating potential and an action potential.

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