Iduronate-2-sulfatase

IDS
Identifiers
Aliases	IDS, MPS2, Siduronate 2-sulfatase
External IDs	OMIM: 300823 MGI: 96417 HomoloGene: 169 GeneCards: IDS
Gene ontology Molecular function • sulfuric ester hydrolase activity • iduronate-2-sulfatase activity • catalytic activity • hydrolase activity • metal ion binding Cellular component • lysosome • lysosomal lumen Biological process • chondroitin sulfate catabolic process • metabolic process • glycosaminoglycan catabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3423	15931
Ensembl	ENSG00000010404	ENSMUSG00000035847
UniProt	P22304	Q08890
RefSeq (mRNA)	NM_000202 NM_001166550 NM_006123	NM_001038990 NM_001038991 NM_010498
RefSeq (protein)	NP_000193 NP_001160022 NP_006114	NP_034628.2 NP_034628
Location (UCSC)	Chr X: 149.48 – 149.52 Mb	Chr X: 70.34 – 70.37 Mb
PubMed search

3423

15931

ENSG00000010404

ENSMUSG00000035847

P22304

Q08890

NM_000202
NM_001166550
NM_006123

NM_001038990
NM_001038991
NM_010498

NP_000193
NP_001160022
NP_006114

NP_034628.2
NP_034628

Iduronate 2-sulfatase (IDS) is a sulfatase enzyme associated with Hunter syndrome.

Iduronate 2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this X-chromosome gene that result in enzymatic deficiency lead to the sex-linked mucopolysaccharidosis type II, also known as Hunter syndrome. Iduronate-2-sulfatase has a strong sequence homology with human arylsulfatases A, B, and C, and human glucosamine-6-sulfatase. A splice variant of this gene has been described.

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