The Innerste Uplands (German: Innerstebergland) is a landscape region up to 359 m high and covering an area of over 900 km² in the northern part of the German Central Uplands. It lies within the eastern part of the Weser-Leine Uplands in Lower Saxony (Germany).
The Innerste Uplands gets its name from the Innerste, a tributary of the River Leine.
The Innerste Uplands cover the catchment area of the Innerste southeast of Hildesheim and southwest to south of Salzgitter as far as Goslar and Seesen on the northwestern edge of the Harz. To the north the area is bounded by the Hildesheim Börde, to the west by the Leine Uplands and to the southeast by the North Harz Foreland. Its central and southern areas are dominated by the Ambergau, a depression dissected by the Nette, a tributary of the Innerste.
In and around the Innerste Uplands there are the following clearly defined ridges, most of which are cuestas and some of which lie on the boundary with neighbouring landscape regions (listed in alphabetical order): Giesen Hills, Hainberg, Harplage, Heber, Hildesheim Forest, Salzgitter Ridge (including the Lichtenberge), Sauberge and Vorholz. Between these ridges run the following rivers: Innerste, Lamme, Neile and Nette together with their tributaries.