| Interstate 81 | ||||
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| Route information | ||||
| Maintained by VDOT | ||||
| Length: | 324.92 mi (522.91 km) | |||
| Major junctions | ||||
| South end: |
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| Highway system | ||||
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I‑381 in Bristol![]()
I‑77 / I‑74 near Wytheville
US 460 in Christiansburg![]()
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I‑73 / I‑581 just north of Roanoke
I‑64 from Lexington to Staunton
US 250 near Staunton
I‑66 near Front Royal