Istradefylline

Istradefylline

Clinical data
ATC code	none
Identifiers
IUPAC name 8-[(E)-2-(3,4-dimethoxyphenyl)vinyl]-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione
CAS Number	155270-99-8 Y
PubChem CID	5311037
IUPHAR/BPS	5608
ChemSpider	4470574 Y
UNII	2GZ0LIK7T4
KEGG	D04641 Y
ChEMBL	CHEMBL431770 Y
ECHA InfoCard	100.230.117
Chemical and physical data
Formula	C20H24N4O4
Molar mass	384.429 g/mol
3D model (JSmol)	Interactive image
SMILES O=C2N(c1nc(n(c1C(=O)N2CC)C)\C=C\c3ccc(OC)c(OC)c3)CC
InChI InChI=1S/C20H24N4O4/c1-6-23-18-17(19(25)24(7-2)20(23)26)22(3)16(21-18)11-9-13-8-10-14(27-4)15(12-13)28-5/h8-12H,6-7H2,1-5H3/b11-9+ Y Key:IQVRBWUUXZMOPW-PKNBQFBNSA-N Y

Istradefylline (KW-6002) is a selective antagonist at the A_2A receptor. It has been found to be useful in the treatment of Parkinson's disease. Istradefylline reduces dyskinesia resulting from long-term treatment with classical antiparkinson drugs such as levodopa. Istradefylline is an analog of caffeine.