Juno (protein)

IZUMO1R
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5JKD, 5F4Q, 5JKB, 5F4E, 5JKA, 5JKC, 5JKE
Identifiers
Aliases	IZUMO1R, Folbp3, JUNO, FOLR4, Juno (protein), IZUMO1 receptor, JUNO
External IDs	MGI: 1929185 HomoloGene: 11283 GeneCards: IZUMO1R
Gene location (Human) Chr. Chromosome 11 (human) Band 11q21 Start 94,305,592 bp End 94,307,721 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band n/a Start 14,885,814 bp End 14,903,949 bp
Gene ontology Molecular function • protein binding • folic acid binding • receptor activity Cellular component • anchored component of membrane • membrane • extracellular region • cell membrane Biological process • single fertilization • C-terminal protein lipidation • cell adhesion • fusion of sperm to egg plasma membrane • sperm-egg recognition Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	390243	64931
Ensembl	ENSG00000183560	ENSMUSG00000031933
UniProt	A6ND01 J3KNP7	Q9EQF4
RefSeq (mRNA)	NM_001080486 NM_001199206	NM_022888 NM_176807
RefSeq (protein)	NP_001186135	NP_075026 NP_789777
Location (UCSC)	Chr 11: 94.31 – 94.31 Mb	Chr 11: 14.89 – 14.9 Mb
PubMed search

5JKD, 5F4Q, 5JKB, 5F4E, 5JKA, 5JKC, 5JKE

390243

64931

ENSG00000183560

ENSMUSG00000031933

A6ND01
J3KNP7

Q9EQF4

NM_001080486
NM_001199206

NM_022888
NM_176807

NP_001186135

NP_075026
NP_789777

Juno also known as folate receptor 4, folate receptor delta or IZUMO1R is a protein that in humans is encoded by the FOLR4 gene. Juno is a member of the folate receptor family and is located on the surface of the mammalian egg cell that recognizes its sperm-riding counterpart, IZUMO1, and facilitates fertilization. The protein was named after Juno, the Roman goddess of fertility and marriage.

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