KCNA2

KCNA2
Identifiers
Aliases	KCNA2, HBK5, HK4, HUKIV, KV1.2, MK2, NGK1, RBK2, EIEE32, potassium voltage-gated channel subfamily A member 2
External IDs	MGI: 96659 HomoloGene: 21034 GeneCards: KCNA2
Targeted by Drug
anandamide
Gene ontology Molecular function • potassium channel activity • voltage-gated ion channel activity • ion channel activity • protein binding • voltage-gated potassium channel activity • delayed rectifier potassium channel activity • outward rectifier potassium channel activity • kinesin binding Cellular component • juxtaparanode region of axon • axon terminus • integral component of membrane • perikaryon • cell projection • endoplasmic reticulum membrane • membrane • voltage-gated potassium channel complex • plasma membrane • synapse • integral component of plasma membrane • neuronal cell body membrane • axon • cell junction • dendrite • endoplasmic reticulum • neuron projection • lamellipodium membrane • presynaptic membrane • lamellipodium • potassium channel complex Biological process • regulation of dopamine secretion • regulation of ion transmembrane transport • ion transport • optic nerve structural organization • potassium ion transport • transmembrane transport • potassium ion transmembrane transport • regulation of circadian sleep/wake cycle, non-REM sleep • transport • protein homooligomerization • protein oligomerization • sensory perception of pain • neuronal action potential Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3737	16490
Ensembl	ENSG00000177301	ENSMUSG00000040724
UniProt	P16389	P63141
RefSeq (mRNA)	NM_001204269 NM_004974	NM_008417
RefSeq (protein)	NP_001191198 NP_004965	NP_032443.3 NP_032443
Location (UCSC)	Chr 1: 110.59 – 110.63 Mb	Chr 3: 107.1 – 107.12 Mb
PubMed search

3737

16490

ENSG00000177301

ENSMUSG00000040724

P16389

P63141

NM_001204269
NM_004974

NM_008417

NP_001191198
NP_004965

NP_032443.3
NP_032443

Potassium voltage-gated channel subfamily A member 2 also known as K_v1.2 is a protein that in humans is encoded by the KCNA2 gene.

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1.

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Wikipedia