KISS1R

Identifiers

KISS1R, AXOR12, CPPB1, GPR54, HH8, HOT7T175, KISS-1R, KiSS1-derived peptide receptor, KISS1 receptor

External IDs

MGI: 2148793 HomoloGene: 11411 GeneCards: KISS1R

Gene ontology
Molecular function	• G-protein coupled peptide receptor activity • G-protein coupled receptor activity • neuropeptide receptor activity • signal transducer activity • protein binding
Cellular component	• integral component of membrane • intracellular membrane-bounded organelle • membrane • plasma membrane • integral component of plasma membrane • cell surface
Biological process	• G-protein coupled receptor signaling pathway • phospholipase C-activating G-protein coupled receptor signaling pathway • signal transduction • neuropeptide signaling pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


84634


114229

Ensembl


ENSG00000116014


ENSMUSG00000035773

UniProt


Q969F8


Q91V45

RefSeq (mRNA)


NM_032551


NM_053244

RefSeq (protein)


NP_115940


NP_444474.1 NP_444474

Location (UCSC)

Chr 19: 0.92 – 0.92 Mb

Chr 10: 79.92 – 79.92 Mb

PubMed search

NP_444474.1
NP_444474

The KiSS1-derived peptide receptor (also known as GPR54 or the Kisspeptin receptor) is a G protein-coupled receptor which binds the peptide hormone kisspeptin (metastin). Kisspeptin is encoded by the metastasis suppressor gene KISS1, which is expressed in a variety of endocrine and gonadal tissues. Activation of the kisspeptin receptor is linked to the phospholipase C and inositol trisphosphate second messenger cascades inside the cell.

Kisspeptin is involved in the regulation of endocrine function and the onset of puberty, with activation of the kisspeptin receptor triggering release of gonadotropin-releasing hormone (GnRH), and release of kisspeptin itself being inhibited by oestradiol but enhanced by GnRH. Reductions in kisspeptin levels with age may conversely be one of the reasons behind age-related declines in levels of other endocrine hormones such as luteinizing hormone.

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