KRT81
| KRT81 | |||||||||||||||||
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| Aliases | KRT81, HB1, Hb-1, KRTHB1, MLN137, ghHkb1, hHAKB2-1, keratin 81 | ||||||||||||||||
| External IDs | MGI: 1928858 HomoloGene: 55645 GeneCards: KRT81 | ||||||||||||||||
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| Species | Human | Mouse | |||||||||||||||
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| Location (UCSC) | Chr 12: 52.29 – 52.29 Mb | Chr 15: 101.46 – 101.46 Mb | |||||||||||||||
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Keratin, type II cuticular Hb1 is a protein that in humans is encoded by the KRT81 gene.
The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix.
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