KRT86

KRT86
Identifiers
Aliases	KRT86, HB6, Hb1, KRTHB1, KRTHB6, MNX, hHb6, K86, keratin 86
External IDs	MGI: 109362 HomoloGene: 1717 GeneCards: KRT86
Gene ontology Molecular function • protein binding • structural molecule activity Cellular component • keratin filament • extracellular exosome • intermediate filament • extracellular space • cytosol Biological process • keratinization • cornification Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3892	16679
Ensembl	ENSG00000170442	ENSMUSG00000067614
UniProt	O43790	P97861
RefSeq (mRNA)	NM_002284 NM_001320198	NM_010667
RefSeq (protein)	NP_001307127	NP_034797.1 NP_034797
Location (UCSC)	Chr 12: 52.25 – 52.31 Mb	Chr 15: 101.47 – 101.48 Mb
PubMed search

3892

16679

ENSG00000170442

ENSMUSG00000067614

O43790

P97861

NM_002284
NM_001320198

NM_010667

NP_001307127

NP_034797.1
NP_034797

Keratin, type II cuticular Hb6 is a protein that in humans is encoded by the KRT86 gene.

The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB1 and KRTHB3, is found primarily in the hair cortex. Mutations in this gene and KRTHB1 have been observed in patients with a rare dominant hair disease, monilethrix.

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