Ki-67 (protein)

MKI67
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1R21, 2AFF
Identifiers
Aliases	MKI67, marker of proliferation Ki-67, KIA, MIB-, MIB-1, PPP1R105
External IDs	MGI: 106035 HomoloGene: 1814 GeneCards: MKI67
Gene ontology Molecular function • nucleotide binding • protein C-terminus binding • protein binding • ATP binding • DNA binding • RNA binding Cellular component • cytoplasm • membrane • chromosome • nucleolus • chromosome, centromeric region • nucleus • condensed chromosome • nuclear body Biological process • cellular response to heat • response to organic cyclic compound • DNA metabolic process • animal organ regeneration • hyaluronan metabolic process • cell cycle • regulation of chromosome segregation • cell proliferation • regulation of mitotic nuclear division • regulation of chromatin organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4288	17345
Ensembl	ENSG00000148773	ENSMUSG00000031004
UniProt	P46013	E9PVX6
RefSeq (mRNA)	NM_001145966 NM_002417	NM_001081117
RefSeq (protein)	NP_001139438 NP_002408	NP_001074586
Location (UCSC)	Chr 10: 128.1 – 128.13 Mb	Chr 7: 135.69 – 135.72 Mb
PubMed search

1R21, 2AFF

4288

17345

ENSG00000148773

ENSMUSG00000031004

P46013

E9PVX6

NM_001145966
NM_002417

NM_001081117

NP_001139438
NP_002408

NP_001074586

Antigen KI-67 also known as Ki-67 or MKI67 is a protein that in humans is encoded by the MKI67 gene (antigen identified by monoclonal antibody Ki-67).

Antigen KI-67 is a nuclear protein that is associated with and may be necessary for cellular proliferation. Furthermore, it is associated with ribosomal RNA transcription. Inactivation of antigen KI-67 leads to inhibition of ribosomal RNA synthesis.

The Ki-67 protein (also known as MKI67) is a cellular marker for proliferation. It is strictly associated with cell proliferation. During interphase, the Ki-67 antigen can be exclusively detected within the cell nucleus, whereas in mitosis most of the protein is relocated to the surface of the chromosomes. Ki-67 protein is present during all active phases of the cell cycle (G₁, S, G₂, and mitosis), but is absent from resting cells (G₀).

...
Wikipedia