Kirksville R-III School District or Kirksville Public Schools is a school district headquartered in Kirksville, Missouri.
As of the 2016-2017 school year the district had 2,464 students and 430 employees, including 222 teachers.
Prior to 2015 about half of its 20-25 English as a second language program students were of Hispanic origin. By 2015 a large number of students from the Democratic Republic of the Congo appeared in Kirksville, doubling the number of ESOL students and giving it a French-speaking population not previously present. Therefore, the district began expanding its ESOL program.