Kvirike IV (Georgian: კვირიკე IV) (died 1102) was a King of Kakheti in eastern Georgia from 1084 to 1102.
He succeeded upon the death of his father Aghsartan I. He ruled as a tributary to the Seljuq dynasty and opposed the energetic Georgian king David IV who pursued a vigorous domestic and foreign policy aimed at asserting Georgia’s integrity and its hegemony in the Caucasus. Kvirike lost the fortress of Zedazeni to David, but wanting to avoid further conflict between “Georgian brothers”, David withdrew his troops and, resolving to end the war in a bloodless and more efficient way, deployed his loyal noblemen and especially, his secret spies, the mstovari. This effort to pressure Kvirike would continue for a few years. Meanwhile Kvirike was still able to secure the succession to his son Aghsartan II.