Kynureninase

kynureninase
Crystal structure of Homo sapiens kynureninase.
Identifiers
EC number	3.7.1.3
CAS number	9024-78-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

KYNU
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2HZP, 3E9K
Identifiers
Aliases	KYNU, KYNUU, kynureninase
External IDs	OMIM: 605197 MGI: 1918039 HomoloGene: 2925 GeneCards: KYNU
Gene ontology Molecular function • protein homodimerization activity • kynureninase activity • catalytic activity • pyridoxal phosphate binding • hydrolase activity Cellular component • cytosol • mitochondrion • cytoplasm Biological process • pyridine nucleotide biosynthetic process • response to vitamin B6 • response to interferon-gamma • NAD biosynthetic process • tryptophan catabolic process to acetyl-CoA • L-kynurenine catabolic process • tryptophan catabolic process • tryptophan catabolic process to kynurenine • quinolinate biosynthetic process • anthranilate metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8942	70789
Ensembl	ENSG00000115919	ENSMUSG00000026866
UniProt	Q16719	Q9CXF0
RefSeq (mRNA)	NM_001032998 NM_001199241 NM_003937	NM_027552 NM_001289593 NM_001289594
RefSeq (protein)	NP_001028170 NP_001186170 NP_003928	NP_001276522.1 NP_001276523.1 NP_081828.1 NP_001276522 NP_001276523 NP_081828
Location (UCSC)	Chr 2: 142.88 – 143.06 Mb	Chr 2: 43.56 – 43.68 Mb
PubMed search

2HZP, 3E9K

8942

70789

ENSG00000115919

ENSMUSG00000026866

Q16719

Q9CXF0

NM_001032998
NM_001199241
NM_003937

NM_027552
NM_001289593
NM_001289594

NP_001028170
NP_001186170
NP_003928

NP_081828

Kynureninase or L-Kynurenine hydrolase (KYNU) (EC 3.7.1.3) is a PLP dependent enzyme that catalyses the cleavage of kynurenine (Kyn) into anthranilic acid (Ant). It can also act on 3hKyn (to produce 3hAnt) and some other (3-arylcarbonyl)-alanines. Humans express one kynureninase enzyme that is encoded by the KYNU gene located on chromosome 2.