LACTB

LACTB
Identifiers
Aliases	LACTB, G24, MRPL56, lactamase beta
External IDs	MGI: 1933395 HomoloGene: 12755 GeneCards: LACTB
Gene location (Human) Chr. Chromosome 15 (human) Band 15q22.2 Start 63,121,800 bp End 63,142,061 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 C Start 66,955,388 bp End 66,975,484 bp
Gene ontology Molecular function • hydrolase activity • peptidase activity • identical protein binding Cellular component • mitochondrion • cytosol Biological process • regulation of lipid metabolic process • proteolysis • lipid metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	114294	80907
Ensembl	ENSG00000103642	ENSMUSG00000032370
UniProt	P83111	Q9EP89
RefSeq (mRNA)	NM_001288585 NM_032857 NM_171846	NM_030717
RefSeq (protein)	NP_001275514 NP_116246 NP_741982	NP_109642
Location (UCSC)	Chr 15: 63.12 – 63.14 Mb	Chr 15: 66.96 – 66.98 Mb
PubMed search

114294

80907

ENSG00000103642

ENSMUSG00000032370

P83111

Q9EP89

NM_001288585
NM_032857
NM_171846

NM_030717

NP_001275514
NP_116246
NP_741982

NP_109642

Serine beta-lactamase-like protein LACTB, mitochondrial is an enzyme that in humans is encoded by the LACTB gene. This gene encodes a 54 kDa protein sharing significant sequence similarity to serine proteases of the penicillin binding protein and beta-lactamase superfamily occurring in bacteria. It is involved in the regulation of the metabolic circuitry. A causal association has been found between LACTB and obesity.

The LACTB gene is located at chromosome 15q22.1, consisting of 8 exons. Alternative splicing results in multiple transcript variants encoding different protein isoforms.

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