LEPR

LEPR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3V6O
Identifiers
Aliases	LEPR, CD295, LEP-R, LEPRD, OB-R, OBR, leptin receptor
External IDs	MGI: 104993 HomoloGene: 1731 GeneCards: LEPR
Gene location (Human) Chr. Chromosome 1 (human) Band 1p31.3 Start 65,420,652 bp End 65,641,559 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 C6|4 46.96 cM Start 101,717,404 bp End 101,815,352 bp
Gene ontology Molecular function • leptin receptor activity • protein binding • identical protein binding • cytokine receptor activity • transmembrane signaling receptor activity Cellular component • integral component of membrane • membrane • receptor complex • plasma membrane • extracellular region • basolateral plasma membrane Biological process • sexual reproduction • glucose homeostasis • leptin-mediated signaling pathway • cholesterol metabolic process • negative regulation of hydrolase activity • regulation of feeding behavior • multicellular organism development • negative regulation of gluconeogenesis • cell surface receptor signaling pathway • T cell differentiation • angiogenesis • energy homeostasis • bone growth • energy reserve metabolic process • response to leptin • negative regulation of autophagy • regulation of bone remodeling • phagocytosis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3953	16847
Ensembl	ENSG00000116678	ENSMUSG00000057722
UniProt	P48357	P48356
RefSeq (mRNA)	NM_002303 NM_001003679 NM_001003680 NM_001198687 NM_001198688 NM_001198689	NM_001122899 NM_010704 NM_146146
RefSeq (protein)	NP_001003679 NP_001003680 NP_001185616 NP_001185617 NP_001185618 NP_002294	NP_001116371 NP_034834 NP_666258
Location (UCSC)	Chr 1: 65.42 – 65.64 Mb	Chr 4: 101.72 – 101.82 Mb
PubMed search

3V6O

3953

16847

ENSG00000116678

ENSMUSG00000057722

P48357

P48356

NM_001198689

NM_001122899
NM_010704
NM_146146

NP_002294

NP_001116371
NP_034834
NP_666258

Leptin receptor also known as LEP-R or OB-R is a Type I cytokine receptor, a protein that in humans is encoded by the LEPR gene. LEP-R functions as a receptor for the fat cell-specific hormone leptin. LEP-R has also been designated as CD295 (cluster of differentiation 295). Its location is the cell membrane, and it has extracellular, trans-membrane, and intracellular sections (protein regions).

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