LGTN

EIF2D
Identifiers
Aliases	EIF2D, HCA56, LGTN, eukaryotic translation initiation factor 2D
External IDs	MGI: 109342 HomoloGene: 38244 GeneCards: EIF2D
Gene ontology Molecular function • translation initiation factor activity • RNA binding • receptor activity Cellular component • cytoplasm • cytosolic small ribosomal subunit • cytosol • nuclear body Biological process • translational initiation • intracellular protein transport • ribosome disassembly • translation • formation of translation preinitiation complex • IRES-dependent viral translational initiation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1939	16865
Ensembl	ENSG00000143486	ENSMUSG00000026427
UniProt	P41214 Q5SY38	Q61211
RefSeq (mRNA)	NM_001201478 NM_006893	NM_001136070 NM_010709
RefSeq (protein)	NP_001188407 NP_008824	NP_001129542 NP_034839
Location (UCSC)	Chr 1: 206.57 – 206.61 Mb	Chr 1: 131.15 – 131.19 Mb
PubMed search

1939

16865

ENSG00000143486

ENSMUSG00000026427

P41214
Q5SY38

Q61211

NM_001201478
NM_006893

NM_001136070
NM_010709

NP_001188407
NP_008824

NP_001129542
NP_034839

Ligatin is a protein that in humans is encoded by the LGTN gene.

This gene encodes a protein receptor that localizes phosphoglycoproteins within endosomes and at the cell periphery. This trafficking receptor for phosphoglycoproteins may play a role in neuroplasticity by modulating cell-cell interactions, intracellular adhesion, and protein binding at membrane surfaces. In hippocampal neurons, long-lasting down-regulation of ligatin mRNA levels occurs via post-transcriptional RNA processing following glutamate receptor activation. This protein contains single PUA and SUI1 domains and these domains may function in RNA binding and translation initiation, respectively.

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Wikipedia