LIFR

LIFR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3E0G
Identifiers
Aliases	LIFR, CD118, LIF-R, SJS2, STWS, SWS, leukemia inhibitory factor receptor alpha, LIF receptor alpha
External IDs	OMIM: 151443 MGI: 96788 HomoloGene: 1735 GeneCards: LIFR
Gene ontology Molecular function • ciliary neurotrophic factor receptor activity • growth factor binding • oncostatin-M receptor activity • protein binding • cytokine receptor activity • ciliary neurotrophic factor receptor binding • leukemia inhibitory factor receptor activity Cellular component • integral component of membrane • membrane • plasma membrane • receptor complex • integral component of plasma membrane • extracellular region • extracellular exosome • extracellular space Biological process • response to cytokine • leukemia inhibitory factor signaling pathway • oncostatin-M-mediated signaling pathway • cytokine-mediated signaling pathway • ciliary neurotrophic factor-mediated signaling pathway • cell surface receptor signaling pathway • positive regulation of cell proliferation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3977	16880
Ensembl	ENSG00000113594	ENSMUSG00000054263
UniProt	P42702	P42703
RefSeq (mRNA)	NM_001127671 NM_002310	NM_001113386 NM_013584
RefSeq (protein)	NP_001121143 NP_002301	NP_001106857.1 NP_038612.1 NP_001106857 NP_038612
Location (UCSC)	Chr 5: 38.47 – 38.61 Mb	Chr 15: 7.13 – 7.2 Mb
PubMed search

3E0G

3977

16880

ENSG00000113594

ENSMUSG00000054263

P42702

P42703

NM_001127671
NM_002310

NM_001113386
NM_013584

NP_001121143
NP_002301

NP_001106857.1
NP_038612.1
NP_001106857
NP_038612

LIFR also known as CD118 (Cluster of Differentiation 118), is a subunit of a receptor for leukemia inhibitory factor.

The leukemia inhibitory factor is a polyfunctional cytokine that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. LIF action appears to be mediated through a high-affinity receptor complex composed of a low-affinity LIF binding chain (LIF receptor) and a high-affinity converter subunit, gp130. Both LIFR and gp130 are members of a family of cytokine receptors that includes components of the receptors for the majority of hematopoietic cytokines and for cytokines that affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin.

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Wikipedia