LRRK2

LRRK2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2ZEJ, 3D6T
Identifiers
Aliases	LRRK2, AURA17, DARDARIN, PARK8, RIPK7, ROCO2, leucine-rich repeat kinase 2, leucine rich repeat kinase 2
External IDs	OMIM: 609007 MGI: 1913975 HomoloGene: 18982 GeneCards: LRRK2
Gene ontology Molecular function • protein homodimerization activity • receptor signaling complex scaffold activity • clathrin binding • co-receptor binding • transferase activity • GTPase activator activity • protein kinase activity • protein kinase A binding • peroxidase inhibitor activity • glycoprotein binding • SNARE binding • nucleotide binding • identical protein binding • GTPase activity • syntaxin-1 binding • protein serine/threonine kinase activity • Rho GTPase binding • tubulin binding • ion channel binding • microtubule binding • MAP kinase kinase activity • GTP binding • ATP binding • GTP-dependent protein kinase activity • beta-catenin destruction complex binding • protein binding • kinase activity • actin binding Cellular component • cytoplasmic vesicle • endosome • intracellular ribonucleoprotein complex • extracellular exosome • Wnt signalosome • neuronal cell body • trans-Golgi network • mitochondrial membrane • synapse • cytoplasm • mitochondrial outer membrane • synaptic vesicle membrane • perikaryon • endoplasmic reticulum • plasma membrane • microvillus • mitochondrial matrix • dendrite cytoplasm • growth cone • cell projection • dendrite • lysosome • neuron projection • Golgi-associated vesicle • mitochondrion • mitochondrial inner membrane • autolysosome • terminal bouton • intracellular • membrane • membrane raft • axon • amphisome • multivesicular body, internal vesicle • synaptic vesicle • inclusion body • cell junction • cytoplasmic side of mitochondrial outer membrane • cytosol • Golgi apparatus • postsynapse • extracellular space • nucleus • intracellular membrane-bounded organelle • caveola neck Biological process • lysosome organization • response to oxidative stress • small GTPase mediated signal transduction • cellular response to dopamine • regulation of autophagy • positive regulation of autophagy • positive regulation of dopamine receptor signaling pathway • regulation of neuroblast proliferation • intracellular distribution of mitochondria • negative regulation of protein processing • negative regulation of protein processing involved in protein targeting to mitochondrion • cellular protein localization • protein localization to mitochondrion • positive regulation of canonical Wnt signaling pathway • autophagy • neuromuscular junction development • phosphorylation • positive regulation of protein binding • regulation of branching morphogenesis of a nerve • mitochondrion localization • positive regulation of protein autoubiquitination • regulation of synaptic vesicle transport • positive regulation of protein phosphorylation • regulation of kidney size • regulation of synaptic vesicle exocytosis • positive regulation of MAP kinase activity • peptidyl-threonine phosphorylation • MAPK cascade • Wnt signalosome assembly • protein phosphorylation • regulation of synaptic transmission, glutamatergic • excitatory postsynaptic potential • negative regulation of hydrogen peroxide-induced cell death • regulation of dopamine receptor signaling pathway • regulation of membrane potential • protein autophosphorylation • regulation of mitochondrial fission • regulation of neuron maturation • reactive oxygen species metabolic process • positive regulation of programmed cell death • regulation of neuron death • regulation of mitochondrial depolarization • cellular response to oxidative stress • activation of MAPK activity • negative regulation of late endosome to lysosome transport • activation of MAPKK activity • GO:0007242 intracellular signal transduction • regulation of lysosomal lumen pH • negative regulation of GTPase activity • locomotory exploration behavior • Golgi organization • canonical Wnt signaling pathway • neuron projection morphogenesis • positive regulation of protein ubiquitination • regulation of canonical Wnt signaling pathway • exploration behavior • cellular response to organic cyclic compound • tangential migration from the subventricular zone to the olfactory bulb • regulation of protein kinase A signaling • calcium-mediated signaling • negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation • negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • negative regulation of neuron death • negative regulation of protein targeting to mitochondrion • peptidyl-serine phosphorylation • determination of adult lifespan • negative regulation of excitatory postsynaptic potential • negative regulation of protein phosphorylation • neuron death • GTP metabolic process • negative regulation of autophagosome assembly • olfactory bulb development • cellular response to starvation • regulation of dendritic spine morphogenesis • cell differentiation • endocytosis • negative regulation of protein binding • mitochondrion organization • cellular response to manganese ion • negative regulation of macroautophagy • regulation of locomotion • positive regulation of GTPase activity • regulation of retrograde transport, endosome to Golgi • regulation of CAMKK-AMPK signaling cascade Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	120892	66725
Ensembl	ENSG00000188906	ENSMUSG00000036273
UniProt	Q5S007	Q5S006
RefSeq (mRNA)	NM_198578	NM_025730
RefSeq (protein)	NP_940980	NP_080006.3 NP_080006
Location (UCSC)	Chr 12: 40.2 – 40.37 Mb	Chr 15: 91.67 – 91.82 Mb
PubMed search

2ZEJ, 3D6T

120892

66725

ENSG00000188906

ENSMUSG00000036273

Q5S007

Q5S006

NM_198578

NM_025730

NP_940980

NP_080006.3
NP_080006

Leucine-rich repeat kinase 2 (LRRK2), also known as dardarin (from the Basque word "dardara" which means trembling), is an enzyme that in humans is encoded by the PARK8 gene. LRRK2 is a member of the leucine-rich repeat kinase family. Variants of this gene are associated with an increased risk of Parkinson's disease and also Crohn's disease.

The LRRK2 gene encodes a protein with an armadillo repeats (ARM) region, an ankyrin repeat (ANK) region, a leucine-rich repeat (LRR) domain, a kinase domain, a RAS domain, a GTPase domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the .

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