LY-379,268

LY-379,268

Identifiers
IUPAC name (1S,2R,5R,6R)-2-amino-4-oxabicyclo[3.1.0]hexane-2,6-dicarboxylic acid
CAS Number	191471-52-0 Y
PubChem CID	10197984
ChemSpider	8373484 N
Chemical and physical data
Formula	C7H9NO5
Molar mass	187.150 g/mol
3D model (JSmol)	Interactive image
SMILES C1[C@]([C@@H]2[C@H]([C@@H]2O1)C(=O)O)(C(=O)O)N
InChI InChI=1S/C7H9NO5/c8-7(6(11)12)1-13-4-2(3(4)7)5(9)10/h2-4H,1,8H2,(H,9,10)(H,11,12)/t2-,3-,4+,7+/m1/s1 N Key:YASVRZWVUGJELU-MDASVERJSA-N N
NY (what is this?)

LY-379,268 is a drug that is used in neuroscience research, which acts as a potent and selective agonist for the group II metabotropic glutamate receptors (mGluR_2/3).

It is derived from the older mGluR group II agonist eglumegad, and led on to the development of the more potent compound LY-404,039, but is still widely used in research itself. LY-379,268 has sedative, neuroprotective, anti-addictive and anticonvulsant effects in animals, and blocks the effects of PCP and DOI, which has led to research into LY-379,268 and similar compounds as antipsychotic drugs for the treatment of schizophrenia in animals.

There are inconsistent findings about an additional activity as a dopamine D2 receptor partial agonist.