Lipid transfer proteins
| Plant lipid transfer protein/seed storage/trypsin-alpha amylase inhibitor | |||||||||
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Oryza sativa Lipid Transfer Protein 1 bound to Palmitic acid (black). Positive charge in blue, negative charge in red. (PDB:1UVB [1])
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| Identifiers | |||||||||
| Symbol | LTP/seed_store/tryp_amyl_inhib | ||||||||
| Pfam | PF00234 | ||||||||
| InterPro | IPR003612 | ||||||||
| SMART | SM00499 | ||||||||
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| Available protein structures: | |
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| Pfam | structures |
| PDB | RCSB PDB; PDBe; PDBj |
| PDBsum | structure summary |
Plant lipid transfer proteins, also known as plant LTPs or PLTPs, are a group of highly-conserved proteins of about 9kDa found in higher plant tissues. As its name implies, lipid transfer proteins are responsible for the shuttling of phospholipids and other fatty acid groups between cell membranes. LTPs are also able to bind acyl groups.
Ordinarily, most lipids do not spontaneously exit membranes because their hydrophobicity makes them poorly soluble in water. LTPs facilitate the movement of lipids between membranes by binding, and solubilising them. LTPs typically have broad substrate specificity and so can interact with a variety of different lipids.
LTPs in plants may be involved in:
Plant lipid transfer proteins consist of 4 alpha-helices in a right-handed superhelix with a folded leaf topology. The structure is stabilised by disulfide bonds linking the helices to each other.
The structure forms an internal hydrophobic cavity in which 1-2 lipids can be bound. The outer surface of the protein is hydrophilic allowing the complex to be soluble. The use of hydrophobic interactions, with very few charged interactions, allows the protein to have broad specificity for a range of lipids.
Plant lipid transfer proteins share the same structural domain with seed storage proteins and trypsin-alpha amylase inhibitors. These proteins share the same superhelical, disulphide-stabilised four-helix bundle containing an internal cavity.
There is no sequence similarity between animal and plant LTPs. In animals, cholesterylester transfer protein (CETP), also called plasma lipid transfer protein, is a plasma protein that facilitates the transport of cholesteryl esters and triglycerides between the lipoproteins.
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