Lipoprotein lipase

LPL
Identifiers
Aliases	LPL, HDLCQ11, LIPD, lipoprotein lipase
External IDs	OMIM: 609708 MGI: 96820 HomoloGene: 200 GeneCards: LPL
Genetically Related Diseases
disease of metabolism, lipid metabolism disorder
Gene ontology Molecular function • triglyceride binding • apolipoprotein binding • heparin binding • lipoprotein lipase activity • triglyceride lipase activity • phospholipase activity • carboxylic ester hydrolase activity • protein binding • receptor binding • hydrolase activity Cellular component • membrane • extracellular matrix • chylomicron • plasma membrane • very-low-density lipoprotein particle • extracellular region • cell surface • anchored component of membrane • extracellular exosome • extracellular space Biological process • lipoprotein metabolic process • positive regulation of inflammatory response • lipid metabolic process • positive regulation of cholesterol storage • positive regulation of chemokine secretion • response to glucose • retinoid metabolic process • triglyceride catabolic process • lipid catabolic process • positive regulation of macrophage derived foam cell differentiation • positive regulation of sequestering of triglyceride • fatty acid biosynthetic process • very-low-density lipoprotein particle remodeling • chylomicron remodeling • response to cold • phospholipid metabolic process • cholesterol homeostasis • triglyceride metabolic process • response to drug • triglyceride homeostasis • triglyceride biosynthetic process • low-density lipoprotein particle mediated signaling Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4023	16956
Ensembl	ENSG00000175445	ENSMUSG00000015568
UniProt	P06858	P11152
RefSeq (mRNA)	NM_000237	NM_008509
RefSeq (protein)	NP_000228	NP_032535.2 NP_032535
Location (UCSC)	Chr 8: 19.9 – 19.97 Mb	Chr 8: 68.88 – 68.91 Mb
PubMed search

Lipoprotein lipase
Identifiers
EC number	3.1.1.34
CAS number	9004-02-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

Search
PMC	articles
PubMed	articles
NCBI	proteins

4023

16956

ENSG00000175445

ENSMUSG00000015568

P06858

P11152

NM_000237

NM_008509

NP_000228

NP_032535.2
NP_032535

Lipoprotein lipase (LPL) (EC 3.1.1.34) is a member of the lipase gene family, which includes pancreatic lipase, hepatic lipase, and endothelial lipase. It is a water-soluble enzyme that hydrolyzes triglycerides in lipoproteins, such as those found in chylomicrons and very low-density lipoproteins (VLDL), into three free fatty acids and one glycerol molecule. It is also involved in promoting the cellular uptake of chylomicron remnants, cholesterol-rich lipoproteins, and free fatty acids. LPL requires ApoC-II as a cofactor.

...
Wikipedia