Loricrin

LOR

Identifiers

LOR, loricrin

External IDs

Gene ontology
Molecular function	• protein binding, bridging • structural constituent of cytoskeleton • protein binding • structural molecule activity • structural constituent of epidermis
Cellular component	• cytoplasm • nucleoplasm • nucleus • cornified envelope • cytosol
Biological process	• peptide cross-linking • keratinization • keratinocyte differentiation • cytoskeleton organization • cornification
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


4014


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Ensembl


ENSG00000203782


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UniProt


P23490


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RefSeq (mRNA)


NM_000427


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RefSeq (protein)


NP_000418


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Location (UCSC)

Chr 1: 153.26 – 153.26 Mb

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PubMed search

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Loricrin is a protein that in humans is encoded by the LOR gene.

Loricrin is a major protein component of the cornified cell envelope found in terminally differentiated epidermal cells.

Loricrin is expressed in the granular layer of all keratinized epithelial cells of mammals tested including oral, esophageal and stomach mucosa of rodents, tracheal squamous metaplasia of vitamin A deficient hamster and estrogen induced squamous vaginal epithelium of rats.

Mutations in the LOR gene are associated with Vohwinkel's syndrome and progressive symmetric erythrokeratoderma, both inherited skin diseases.

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