"Lose the Boss" is an episode from the dramedy series Ugly Betty, which aired on November 23, 2006. In the United States, Canada and Australia, it is the ninth episode but it's the tenth overall and was written by Oliver Goldstick and directed by Ken Whittingham. This episodes's title is a pun on a former ABC sitcom, Who's the Boss?, which starred Judith Light, who became a regular on this series.

It's the day after Thanksgiving. A hungover Daniel finds himself waking up in his black socks and boxers in Betty's bed. She reminds him that she picked him up drunk in a bar last night. When he asks her where she slept, her answer was 'In your arms,' but she's just teasing; she actually slept on the couch. He bitterly tells her that Sofia ran away with her perfect boyfriend and 'his perfect chin' (aka Hunter, her fiance). She tries to reassure him that a lot can change in a short time and tucks him back into bed. Betty goes downstairs and tells her father to be nice to Daniel when he wakes up. Another surprise guest, Santos, walks into the kitchen in a kimono and Ignacio says he liked it better when he sneaked out in the middle of the night. Daniel eventually comes down and tries to leave quietly, but Ignacio finds him and pulls him into the kitchen. Santos begins to compliment Daniel on his publicized history with the ladies before Ignacio brings Daniel a plate of food that sends him running to the bathroom.

Meanwhile back at MODE, Wilhelmina is going through the litany of destructions that befell her office to Marc. He tried to pretend that he was in Schenectady on Thanksgiving, but she knows that it was him after she discovered the 15 grams of fat left behind in the form of a cashew Amanda dropped. However that issue would be put aside when Bradford calls to tell Wilhelmina to turn on Fashion TV where they see Isaac Mizrahi reporting on an elusive sought-after couple. Bradford then tells her that they've been chosen to reveal 'baby Chutney' (the newborn of celebrity couple Tim and Chloe) to the world for the first time.

Betty walks into the office and finds Sofia leaving a note for Daniel; he hasn't been calling her back. She begins to go on about her marriage plans with Hunter before confessing to Betty that she isn't sure anymore, but would Daniel even care? Betty tries to feign disinterest and they return to work.

Bradford comes down looking for Daniel, worried about the photo shoot for Tim and Chloe's baby. Sofia has offered to do the writing. Betty calls Daniel, still mildly drunk and mollycoddled on the sofa by Justin and Ignacio. He tells Betty that he is not going anywhere and he's having a Christmas tree delivered to her family. Betty begins to wonder how she will get this shoot taken care of. While Justin starts to tell Daniel about issues of MODE he's saved, Ignacio slips away to ask Hilda how long she thinks Santos will stay this time, now that Hilda and Santos had their night of lovemaking.

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