Low affinity nerve growth factor receptor

NGFR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3EWV, 2N80, 2N97, 2N83
Identifiers
Aliases	NGFR, CD271, Gp80-LTNFRSF16, p75(NTR), p75NTR, nerve growth factor receptor
External IDs	MGI: 97323 HomoloGene: 1877 GeneCards: NGFR
Gene ontology Molecular function • signal transducer activity • Rab GTPase binding • transmembrane signaling receptor activity • receptor activity • tumor necrosis factor-activated receptor activity • ubiquitin protein ligase binding • protein binding • calmodulin binding • coreceptor activity • neurotrophin binding • nerve growth factor binding Cellular component • extracellular region • nucleoplasm • integral component of membrane • cytosol • integral component of plasma membrane • neuron projection • membrane • cell surface • endosome • nucleus • plasma membrane Biological process • rhythmic process • regulation of cysteine-type endopeptidase activity involved in apoptotic process • negative regulation of apoptotic process • neurotrophin TRK receptor signaling pathway • signal transduction • axon guidance • multicellular organism development • apoptotic process • negative regulation of axonogenesis • nervous system development • glucose homeostasis • positive regulation of axonogenesis • circadian regulation of gene expression • membrane protein intracellular domain proteolysis • regulation of glucose import in response to insulin stimulus • cell differentiation • inflammatory response • immune response • intracellular protein transport • positive regulation of apoptotic process • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • tumor necrosis factor-mediated signaling pathway • response to lipopolysaccharide • apoptotic signaling pathway • negative regulation of neuron projection development • activation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of protein localization to nucleus • positive regulation of pri-miRNA transcription from RNA polymerase II promoter • negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis • Rho protein signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4804	18053
Ensembl	ENSG00000064300	ENSMUSG00000000120
UniProt	P08138	Q9Z0W1 Q8CFT3
RefSeq (mRNA)	NM_002507	NM_033217
RefSeq (protein)	NP_002498	NP_150086
Location (UCSC)	Chr 17: 49.5 – 49.52 Mb	Chr 11: 95.57 – 95.59 Mb
PubMed search

3EWV, 2N80, 2N97, 2N83

4804

18053

ENSG00000064300

ENSMUSG00000000120

P08138

Q9Z0W1
Q8CFT3

NM_002507

NM_033217

NP_002498

NP_150086

The low-affinity nerve growth factor receptor (nerve growth factor receptor (TNFR superfamily, member 16), also called the LNGFR or p75 neurotrophin receptor) is one of the two receptor types for the neurotrophins, a family of protein growth factors that stimulate neuronal cells to survive and differentiate. LNGFR is a member of the tumor necrosis factor receptor (TNF receptor)superfamily - indeed, LNGFR was the first member of this large family of receptors to be characterized.

The neurotrophins are composed of four proteins, all of which bind to the LNGFR: nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4).

...
Wikipedia